Tumor mutational load predicts survival after immunotherapy across multiple cancer types
نویسندگان
چکیده
منابع مشابه
Comprehensive identification of mutational cancer driver genes across 12 tumor types
With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous molecular nature of the disease and the limitations of available computational methods. Here we show that the combination of complementary methods allows identifying a c...
متن کاملAntibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like
Here, we propose a new strategy for the treatment of early cancerous lesions and advanced metastatic disease, via the selective targeting of cancer stem cells (CSCs), a.k.a., tumor-initiating cells (TICs). We searched for a global phenotypic characteristic that was highly conserved among cancer stem cells, across multiple tumor types, to provide a mutation-independent approach to cancer therapy...
متن کاملA breast cancer prognostic signature predicts clinical outcomes in multiple tumor types.
Epidemiological studies indicate an increased risk of subsequent primary ovarian cancer from women with breast cancer. We have recently identified a 28-gene expression signature that predicts, with high accuracy, the clinical course in a large population of breast cancer patients. This prognostic gene signature also accurately predicts response to chemotherapy commonly used for treating breast ...
متن کاملTumor Mutational Load and Immune Parameters across Metastatic Renal Cell Carcinoma Risk Groups.
Patients with metastatic renal cell carcinoma (mRCC) have better overall survival when treated with nivolumab, a cancer immunotherapy that targets the immune checkpoint inhibitor programmed cell death 1 (PD-1), rather than everolimus (a chemical inhibitor of mTOR and immunosuppressant). Poor-risk mRCC patients treated with nivolumab seemed to experience the greatest overall survival benefit, co...
متن کاملCirculating tumor cells count predicts survival in colorectal cancer patients.
BACKGROUND AND AIMS Data on the potential of circulating tumor cells (CTC) count in predicting overall survival (OS) in patients with colorectal cancer are timely and worthy of interest. This study aimed to evaluate the prognostic role of CTC count in both localized and metastatic colorectal cancer patients. METHODS Consecutive patients with histological diagnosis of colorectal cancer were en...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Genetics
سال: 2019
ISSN: 1061-4036,1546-1718
DOI: 10.1038/s41588-018-0312-8